ANSC 618

LIPIDS & LIPID METABOLISM

INSTRUCTOR: Stephen B. Smith
OFFICE: 338A Kleberg Center
PHONE: 845-3939
Room 123, Kleberg Center
Tues-Thurs, 12:45 - 2:00

OBJECTIVES:

Upon completion of this course, the student should be able to:

Describe the chemical nature of the various classes of lipids and lipid-derived hormones.
Discuss the absorption and metabolism (synthesis/degradation/modification) of fatty acids and lipids.
Integrate the regulation of lipid biosynthesis and obesity.
Describe the relationship between lipid metabolism and cholesterol homeostasis.

PREREQUISITE: BICH 410 or approval of instructor.

REQUIRED READING MATERIAL:

TEXT: The Biology of Fat in Meat Animals: Current Advances. This text will be used to provide supporting material for the lectures, particularly for Sections III & IV.

HANDOUTS. Several handouts will be distributed throughout the semester. These will provide outlines of the lecture material and supplementary reading for Sections I & II.

GRADING:

Exam	Points
Midterm I	100 points
Midterm II	100 points
Midterm III	100 points
Final	100 points
TOTAL	400 points

Each exam will cover one of the four sections. Exams will be based heavily on lecture material. The handouts and assigned reading will provide clarification and additional background. Exams will be a combination of matching, short answer and integrative questions. Grades will be based on examination scores: 90 - 100%, A; 80 - 89%, B; etc.

ATTENDANCE:

Absences for illness or official University business are acceptable. However, the students have full responsibility for the material covered during their absence.

LECTURE OUTLINE

Date	Topic	Assigned Reading
Week 1	Section I. Fatty Acid, Triglyceride, and Phospholipid Chemistry
	Course Introduction
	General Chemistry and Nomenclature of Fatty Acids	Handouts
Week 2
	Triglyceride Structure/Methods for Determination	Handouts
	Dietary Fatty Acids/Effects on Tissue Fatty Acid Composition	Handouts
Week 3
	Effects of Diet and Species on Triglyceride Structure	Handouts
	Membrane Lipid Chemistry	Handouts
Week 4	Section II. Lipid and Cholesterol Absorption and Transport
	Digestion and Absorption of Lipids	Handouts
	EXAM I
Week 5
	Chylomicrons and Lipoprotein Lipase	Handouts
	Cholesterol Synthesis	Handouts
Week 6
	Dietary Sources of Cholesterol and Cholesterol Absorption	Handouts
	Lipoprotein Metabolism	Handouts
Week 7
	The LDL Receptor	Handouts
	Dietary Fat/Cholesterol and Heart Disease	Handouts
Week 8	Section III. Fatty Acid Metabolism
	Fatty Acid Biosynthesis, Elongation and Desaturation	Chapter 10
	EXAM II
Spring Break
Week 9
	Glucose Metabolism and Lipid Synthesis	Chapter 10
	Provision of NADPH for Fatty Acid Synthesis	Chapter 10
Week 10
	Glycerolipid Biosynthesis	Chapters 8 & 10
	Lipolysis and Fatty Acid Oxidation	Chapters 1, 2 & 6
Week 11
	Adrenergic and Adenosine Regulation of Lipid Metabolism	Chapters 1 & 2
	Insulin and Somatotropin Regulation of Lipid Metabolism	Chapters 2, 3 & 7
Week 12	Section IV. Obesity
	Adipocyte Precursors	Chapters 4 & 5
	EXAM III
Week 13
	Specific Gene Expression in Adipose Tissue	Chapter 10
	Differentiation and Dedifferentiation of Adipocytes	Handouts
Week 14
	Interconversion of Brown & White Adipose Tissues	Chapter 10
	Nonshivering Thermogenesis and Obesity	Handouts
Week 15
	Hormonal Regulation of Obesity	Chapters 1 & 3
	University Reading Day - No Class
	FINAL EXAMINATION